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Nov 30, 2020 · Researchers have been wrestling with the problem at least since the 1970s, when Christian Anfinsen won the Nobel prize for showing that sequences determined structure.
Jun 12, 2023 · Despite initial excitement and ongoing hopes for the future, one cannot say that the protein folding problem has been well and truly solved – at least not yet.
Dec 8, 2020 · How proteins get there, and many other problems related to protein folding, remain unsolved. Synergies between AlphaFold and Folding@home could enable more progress. DeepMind recently claimed they solved the protein folding problem with their AlphaFold algorithm.
Nov 30, 2020 · In a major scientific advance, the latest version of our AI system AlphaFold has been recognised as a solution to this grand challenge by the organisers of the biennial Critical Assessment of protein Structure Prediction (CASP).
Mar 17, 2025 · Herein, we report the results of 3,255 experiments with AF3 to evaluate its ability to predict the fold, chirality, and binding pose of D-peptides in heterochiral complexes.
In living organisms, every protein – a type of biological polymer consisting of hundreds of amino acids – carries out specific functions, such as catalysis, molecule transport, or DNA repair. To perform these functions, they must fold up into specific shapes.
Oct 31, 2022 · Figuring out a single protein’s structure, or solving the “protein-folding problem,” can take years of finicky experiments. But last year an artificial-intelligence program called...
Sep 23, 2022 · For many researchers, the dream has been to have computer programs that could examine the DNA of a gene and predict how the protein it encodes would fold into a 3-D shape.
Feb 3, 2022 · Some may feel that this problem will have been solved once any method has been found that enables one to obtain accurate predictions of the structures of proteins from their sequences.
Many would agree that the two main issues in computational protein folding, as opposed to theories of folding, are the accuracy of the force fields and the issue of sampling the degrees of freedom.
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